CO2/O2 gas analyzer for cell growth processes - BlueInOne Cell

The analyzer for carbon dioxide and oxygen has been specially designed for monitoring cell growth processes in biotechnology. The device can be installed directly in the exhaust flow of the bioprocess and measures the concentration of CO2 and O2 there in real-time.

The BlueInOne Cell automatically compensates any fluctuations of pressure and humidity in the system. The readings are therefore extremely accurate even under fluctuating measuring conditions. The BlueInOne Cell gas analyzer is fitted with an IR CO2 sensor, as well as a new electrochemical oxygen sensor with galvanic cell.

The O2 detector offers a measuring range of 0-100 % Vol. for oxygen, long-term stability and has a very high resolution of 50 ppm. The device can also analyze anaerobic processes with high precision.

BlueInOne Cell - understanding bioprocesses.

The modern BlueInOne Cell incorporates all measuring components in one compact and durable stainless steel housing and is very easy to install directly on the gas pipe. Using standard interfaces, such as Modbus or USB, it can be connected to any process control system or PC. With automatic, continuous monitoring and documentation of the growth process, there is no need for sampling. The operating status of the BlueInOne Cell can be read anytime by checking the illuminated buttons.

This latest generation of gas analyzer can be easily connected up any pipe or hose connection of between 4mm and 1¼" and measures the process directly. The BlueInOne could be used as a replacement for cost-intensive mass spectrometers.

Advantages:

  • Parallel measurement of O2 and CO2
  • Modbus OPC server available
  • O2 concentrations form 0-100 Vol.%
  • No oxygen needed in the process
  • Compact stainless steel housing
  • PAT and QbD conform in-situ-measurement
  • Auto compensated humidity and pressure
  • No gas cooler, pumps or valves needed
  • Connectable to any hose or tube from 4mm to 1 ¼"
  • Real time process optimization
  • Status display by luminous pushbuttons

Concentration ranges (others on request):

1. CO2: 0 - 10 Vol.%, O2: 0 - 100 Vol.%

2. CO2: 0 - 25 Vol.%, O2: 0 - 100 Vol.%

 

Measuring principle:

IR(CO2), Galvanic cell (O2)

Temperature inside of the sensor unit:

3°C / 5.4°F higher than process temperature

Application areas:

  • Cell growth processes
  • Cell culture
  • Biotechnology
  • Online fermentation monitoring
  • From lab to industrial scale

Soft sensors:

Together with the Bioprocessing software BlueVis the following soft sensors are available:

  • CER
  • OUR
  • RQ
  • Biomass by EXPUTEC
  • Growth rate by EXPUTEC

The usability of the soft sensors depends on the set-up of the process and may require additional equipment.

Display

Optional display for the BlueInOne

For all the BlueInOne gas analyzers there is a convenient additional display available now. It shows the current measurement data of the CO2 and O2 concentration. So you have the present measurement always directly in view. The display is simply connected via an up to 5 meters long data cable to the analogue 4-20mA output of the BlueInOne analyzer. Magnets at the backside of the housing of the display make the mounting easy and convenient. The display also has got a 4-20mA port, which passes the analog signal from BlueInOne. Thus, no ports are blocked by the display. In addition, the display has a practical button to perform a 1-point calibration. Thus, the calibration can also be started very simply, if the BlueInOne is not easy to reach. The display is supplied via the power from the 4-20 mA output and requires no external power supply and no batteries. There are versions for each BlueInOne; also devices that are already in use can be upgraded.

Advantages:

  • Convenient: the current measured values directly on site in view
  • Easy installation: quick control without software
  • Flexible to install, easy mounting
  • Time savings: start the one-point calibration easily even if the BlueInOne is hard to reach
  • 4-20 mA port included, no ports are blocked
  • Variants for all BlueInOne available

Easy to install

The BlueInOne is very easy to install via various mechanical connections. Usually the BlueInOne is installed in the exhaust pipe. We offer many hose nozzles, quick connector, Tri-Clamp connections and screw connections. See here a list of standard designs:

Other mechanical connections can be implemented on request.

The new BlueVis software. The ideal tool for the BlueInOne.

The BlueVis software is the most convenient solution to operate the BlueInOne gas analyzers. It logs and visualizes the data and is a maintenance-tool for the monthly calibration as well. This Bioprocessing software calculates the oxygen uptake rate (OUR), carbon dioxide emission rate (CER) and respiratory quotient (RQ) automatically by the collected data of the BlueInOne analyzer and the given process parameters. Up to 12 processes can be easily managed by this program.   

(more about the BlueVis)

General brochure BlueInOne

(PDF-File, 3 MB)


 

 

Information Display

(PDF-Datei, 400 KB)


 

 

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